多肽合成丨中间体 Alamandine CAS号: 1176306-10-7

名称：Alamandine

CAS号：1176306-10-7

序列：
H-Ala-Arg-Val-Tyr-Ile-His-Pro-OH

分子式：C40H62N12O9

分子量：855

纯度：>98.0%

细节：

Alamandine是一种内源性七肽，可以由血管紧张素A通过血管紧张素转换酶-2形成，也可以直接由血管紧张肽-（1-7）通过其天冬氨酸残基的脱羧形成。Alamandine的活性与Ang-（1-7）相似，而不是血管紧张素II或血管紧张素A。然而，Alamandine作用于不同的受体，即Mas相关受体MrgD。Alamandine引起血管舒张，并具有抗纤维化和抗高血压活性。

Details:
Alamandine is an endogenous heptapeptide that can be formed from angiotensin A by angiotensin converting enzyme-2 or directly from angiotensin-(1–7) by decarboxylation of its aspartate residue. Alamandine′s activity is similar to Ang-(1–7) rather than that of angiotensin II or angiotensin A. However, Alamandine acts at a different receptor, the Mas-related receptor, MrgD. Alamandine causes vasodilation, and has antifibrosis and antihypertensive activity.

*成都云希youngshe2015