Colivelin CAS号：867021-83-8 序列：SALLRSIPAPAGASRLLTLGEIDLP

产品名称：Colivelin

CAS号：867021-83-8

序列：SALLRSIPAPAGASRLLTLGEIDLP

分子式：C119H206N32O35

分子量：2645.14

纯度：>95.0%

来源：合成

MSDS和COA：可提供

详细信息：Colivelin是一种杂合肽，可介导对阿尔茨海默病（AD）相关损伤的神经保护。它由活性依赖性神经营养因子（ADNF）C末端融合到AGA（C8R）HNG17组成，AGA是一种强效的人源蛋白衍生物。Colivelin在100 fM的浓度下完全抑制了由过表达家族性AD致病基因和淀粉样β蛋白（1-43）（H-1586）引起的死亡。腹膜内注射肽抑制了毒蕈碱乙酰胆碱受体拮抗剂3-奎宁环苄基酯引起的记忆障碍，表明腹膜内注射Colivelin的很大一部分通过血脑屏障。

*仅用于研究

Name: Colivelin

CAS No. : 867021-83-8

Sequence: SALLRSIPAPAGASRLLLLTGEIDLP

Molecular formula: C119H206N32O35

Molecular weight : 2645.14

Purity: >95.0%

Source: synthetic

MSDS and COA: available

Details: Colivelin is a hybrid peptide which mediates neuroprotection against Alzheimer's disease (AD)-relevant insults. It is composed of activity-dependent neurotrophic factor (ADNF) C-terminally fused to AGA(C8R)HNG17, a potent humanin derivative. Colivelin completely suppressed death induced by overexpressing familial AD-causative genes and amyloid β-protein (1-43) (H-1586) at a concentration of 100 fM. Intraperitoneally administered peptide suppressed memory impairment caused by the muscarinic acetylcholine receptor antagonist, 3-quinuclidinyl benzylate, indicating that a substantial portion of intraperitoneally administered colivelin passes through the blood brain barrier.

*only for research

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